Corinne Bousquet

Investigating the role for CAF (cancer-associated fibroblast)-derived SLITs on pancreatic cancer and immune cell behavior
Develop multiplex immunofluorescence imaging to monitor subsets of cancer-associated fibroblasts
Using bioinformatics, search for specific cancer-associated fibroblast subsets signatures in link with ROBOs and SLITs expression in pancreatic tumors
From spatial transcriptomics analyses on pancreatic cancer tissues, perform in silico modeling of interactions between ROBOs-expressing and SLITs secreting cancer, immune, endothelial cells and cancer-associated fibroblasts

Partner 2

1Expertise in pancreatic cancer microenvironment, focusing on cancer-associated fibroblasts
Cultures of primary cancer-associated fibroblasts (isolated from patient pancreatic tumors), and immortalization of some lines
2D and 3D co-cultures of cancer-associated fibroblasts with pancreatic cancer cells, and functional associated assays
In vivo monitoring of pancreatic cancer cells growth, invasion and resistance to therapies
Expertise and tool development for multi-omics integrative approaches, machine learning and network theory as well as mathematical models to describe and simulate the tumor microenvironment